DiscoveRx


Changing the GPCR Screening Paradigm

PathHunter™ ß-arrestin GPCR assays detect primary rather than secondary activation events, offering less opportunity for off-target effects. The assays typically also provide larger assay windows than calcium or cAMP and can be run in the same well as the latter. Pharmacological data, technology information, and ordering information for validated targets are accessible using the links below. Please contact us for information about our custom assay development and GPCR profiling services.

Cell-Based ß-Arrestin GPCR Assays
Target Details Available for Profiling Catalog# Price
ADCYAP1R1 (PAC1) Dose Curve Yes 93-0249C2 Quote
ADCYAP1R1(PAC1) Dose Curve No Quote
ADKRB2 Dose Curve No 93-0189C2 Quote
more Cell-Based ß-Arrestin GPCR Assays...

Cell-Based β-Arrestin Ortholog GPCR Assays
Target Details Available for Profiling Catalog# Price
cEDG5 Dose Curve No 93-0581C2 Quote
cSUCNR1 (pool) Dose Curve No 93-0589P2 Quote
mADCYAP1R1 Dose Curve No 93-0594C2 Quote
more Cell-Based β-Arrestin Ortholog GPCR Assays...

Cell-Based ß-Arrestin Orphan GPCR Assays
Target Details Available for Profiling Catalog# Price
ADMR (pool) Expression Yes 93-0403P2 Quote
BAI1 Expression Yes 93-0545C2 Quote
BAI2 Expression Yes 93-0546C2 Quote
more Cell-Based ß-Arrestin Orphan GPCR Assays...

Assay Development Tools
Products Details Available for Profiling Catalog# Price
CHO-K1 EA-Arrestin Parental Cell Line Data No 93-0164 Quote
HEK 293 EA-Arrestin Parental Cell Line Data No 93-0165 Quote
pCMV-PK Vector Data No 93-0167 Quote
more Assay Development Tools...

Detection Kits
Product Description Available for Profiling Catalog# Price
EAstern Blot Assay Kit EFC detection for solid membranes No 93-0053 Quote
PathHunter™ Detection Kit Standard glow EFC luminescence No 93-0001 Quote
PathHunter™ EA Detection Kit Enzyme Acceptor protein detection No 93-0183 Quote
more Detection Kits...

Note that some EC50 values are right shifted, however many agree with existing GPCR-Ligand binding data. Please contact us at info@discoverx.com for details.

Interested in other cell types, Custom Assays or GPCR profiling? Email us at info@discoverx.com