Cell-Based ß-Arrestin GPCR Assays
   Cell-Based β-Arrestin Ortholog GPCR Assays
   Cell-Based ß-Arrestin Orphan GPCR Assays
   Assay Development Tools
   Detection Kits
   GPCR Cell Lines
    cAMP Hunter™
   Cell-Based Kinase Assays
    PathHunter™ Cell-Based
    PhosphoQuest™
   Assay-Ready
    cAMP Hunter™ eXpress
    PathHunter™ eXpress ß-Arrestin GPCR Kits
    PathHunter eXpress ß-Arrestin Kits for Caliper LabChip®
   PathHunter™ NHR
   DiscoveRx

 


Changing the GPCR Screening Paradigm

PathHunter™ ß-arrestin GPCR assays detect primary rather than secondary activation events, offering less opportunity for off-target effects. The assays typically also provide larger assay windows than calcium or cAMP and can be run in the same well as the latter. Pharmacological data, technology information, and ordering information for validated targets are accessible using the links below. Please contact us for information about our custom assay development and GPCR profiling services.

Cell-Based ß-Arrestin GPCR Assays
Target Details Available for Profiling Catalog# Price
ADCYAP1R1 (PAC1) Dose Curve Yes 93-0249C1 Quote
ADORA1 Dose Curve Yes 93-0185C1 Quote
ADORA2B Dose Curve Yes 93-0272C2 Quote
more Cell-Based ß-Arrestin GPCR Assays...

Cell-Based β-Arrestin Ortholog GPCR Assays
Target Details Available for Profiling Catalog# Price
mADORA2B Dose Curve Yes 93-0469C2 Quote
mCCR5 Dose Curve Yes 93-0470C2 Quote
mCNR1 Dose Curve Yes 93-0471C2 Quote
more Cell-Based β-Arrestin Ortholog GPCR Assays...

Cell-Based ß-Arrestin Orphan GPCR Assays
Target Details Available for Profiling Catalog# Price
ADMR Expression Yes 93-0403P2 Quote
CCRL2 Expression Yes 93-0333P2 Quote
EBI2 Expression Yes 93-0437P2 Quote
more Cell-Based ß-Arrestin Orphan GPCR Assays...

Assay Development Tools
Products Details Available for Profiling Catalog# Price
CHO-K1 EA-Arrestin Parental Cell Line Data No 93-0164 Quote
HEK 293 EA-Arrestin Parental Cell Line Data No 93-0165 Quote
pCMV-PK Vector Data No 93-0167 Quote
more Assay Development Tools...

Detection Kits
Product Description Available for Profiling Catalog# Price
EAstern Blot Assay Kit EFC detection for solid membranes No 93-0053 Quote
PathHunter™ Detection Kit Standard glow EFC luminescence No 93-0001 Quote
PathHunter™ EA Detection Kit Enzyme Acceptor protein detection No 93-0183 Quote
more Detection Kits...

Note that some EC50 values are right shifted, however many agree with existing GPCR-Ligand binding data. Please contact us at info@discoverx.com for details.

Interested in other cell types, Custom Assays or GPCR profiling? Email us at info@discoverx.com