Cell-Based ß-Arrestin GPCR Assays
   Cell-Based ß-Arrestin Orphan GPCR Assays
   Assay Development Tools
   Detection Kits
   GPCR Cell Lines
    cAMP Hunter™
   PhosphoQuest™ Kinase Assays
   PathHunter™ NHR
   PathHunter™ eXpress
   DiscoveRx

 


Changing the GPCR Screening Paradigm

PathHunter™ ß-arrestin GPCR assays detect primary rather than secondary activation events, offering less opportunity for off-target effects. The assays typically also provide larger assay windows than calcium or cAMP and can be run in the same well as the latter. Pharmacological data, technology information, and ordering information for validated targets are accessible using the links below. Please contact us for information about our custom assay development and GPCR profiling services.

Cell-Based ß-Arrestin GPCR Assays
Target Details Available for Profiling Catalog# Price
ADCYAP1R1 (PAC1) Dose Curve No 93-0249P1 Quote
ADORA1 Dose Curve Yes 93-0185C1 Quote
ADORA2B Dose Curve Yes 93-0272C2 Quote
more Cell-Based ß-Arrestin GPCR Assays...

Cell-Based ß-Arrestin Orphan GPCR Assays
Target Details Available for Profiling Catalog# Price
CCRL2 Dose Curve Yes 93-0333C2 Quote
FKSG80 Dose Curve Yes 93-0330C2 Quote
GHSR1b Dose Curve No 93-0354P2 Quote
more Cell-Based ß-Arrestin Orphan GPCR Assays...

Assay Development Tools
Products Details Available for Profiling Catalog# Price
CHO-K1 EA-Arrestin Parental Cell Line Data No 93-0164 Quote
HEK 293 EA-Arrestin Parental Cell Line Data No 93-0165 Quote
pCMV-PK Vector Data No 93-0167 Quote
more Assay Development Tools...

Detection Kits
Product Description Available for Profiling Catalog# Price
EAstern Blot Assay Kit EFC detection for solid membranes No 93-0053 Quote
PathHunter™ Detection Kit Standard glow EFC luminescence No 93-0001 Quote
PathHunter™ EA Detection Kit Enzyme Acceptor protein detection No 93-0183 Quote
more Detection Kits...

Note that some EC50 values are right shifted, however many agree with existing GPCR-Ligand binding data. Please contact us at info@discoverx.com for details.

Interested in other cell types, Custom Assays or GPCR profiling? Email us at info@discoverx.com